Cancer Communications
indexed by SCI
BMC

Review
Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer
Xiangyu Zhang
Department of Pathology, Jining First People??s Hospital, Jining Medical University, No. 6 Jiankang Road, Jining, 272000, Shandong, P. R. China
[Abstract] Bone metastasis is the leading cause of death in prostate cancer patients, for which there is currently no effective treatment. Since the bone microenvironment plays an important role in this process, attentions have been directed to the interactions between cancer cells and the bone microenvironment, including osteoclasts, osteoblasts, and bone stromal cells. Here, we explained the mechanism of interactions between prostate cancer cells and metastasis-associated cells within the bone microenvironment and further discussed the recent advances in targeted therapy of prostate cancer bone metastasis. This review also summarized the effects of bone microenvironment on prostate cancer metastasis and the related mechanisms, and provides insights for future prostate cancer metastasis studies.
Cancer Communications   Epub date: 11/21/2019   doi:10.1186/s40880-019-0425-1
[PDF Full-text]

[ Html full-text] (BioMed Central)

[ PubMed]

Cite this article

Xiangyu Zhang . Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer. Cancer Commun (Lond). 2019, 39:76. doi:10.1186/s40880-019-0425-1


Export citations

EndNote

CJC Wechat 微信公众号


 

Editorial Manager


CC adopts ScholarOne Manuscripts to manage its submissions from Nov.1, 2019

 Submission Guidelines  

 

Reference style for  

 EndNote,
 Reference Manager



Editorial Manager


 

Year:

 

Month:

Advanced search

Subscription


CC is now published by Wiley

© Cancer Communications

651 Dongfeng Road East, Guangzhou 510060, P. R. China