Cancer Communications
indexed by SCI
BMC

Original article
Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma
You-Ping Liu, Xing Lv, Xiong Zou, Yi-Jun Hua, Rui You, Qi Yang, Le Xia, Shao-Yan Guo, Wen Hu, Meng-Xia Zhang, Si-Yuan Chen, Mei Lin, Yu-Long Xie, Li-Zhi Liu, Rui Sun, Pei-Yu Huang, Wei Fan, Xiang Guo, Ming-Huang Hong & Ming-Yuan Chen
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510060, Guangdong, P. R. China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China
[Abstract]

Background
The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy (IMRT) as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma (NPC), but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients. Endoscopic nasopharyngectomy (ENPG) was successfully applied in recurrent NPC with radiation free and relatively low medical costs. In this study, we examined whether ENPG could be an effective treatment for localized stage I NPC.
Methods
Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center. Simultaneously, the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort. The survival outcomes, quality of life (QOL), and medical costs between two groups were compared.
Results
After a median follow-up of 59.0 months (95% CI 53.4?C64.6), no death, locoregional recurrence, or distant metastasis was observed in the 10 patients treated with ENPG. The 5-year overall survival, local relapse-free survival, regional relapse-free survival, and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients (100% vs. 99.1%, 100% vs. 97.7%, 100% vs. 99.0%, 100% vs. 97.4%, respectively, P > 0.05). In addition, compared with IMRT, ENPG was associated with decreased total medical costs ($ 4090.42 ?? 1502.65 vs. $ 12620.88 ?? 4242.65, P < 0.001) and improved QOL scores including dry mouth (3.3 ?? 10.5 vs. 34.4 ?? 25.8, P < 0.001) and sticky saliva (3.3 ?? 10.5 vs. 32.6 ?? 23.3, P < 0.001).
Conclusions
ENPG alone was associated with promising long-term survival outcomes, low medical costs, and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy. However, the application of ENPG should be prudent, and prospective clinical trials were needed to further verify the results.
Cancer Communications   Epub date: 11/15/2019   doi:10.1186/s40880-019-0415-3
[PDF Full-text]

[ Html full-text] (BioMed Central)

[ PubMed]

Cite this article

You-Ping Liu, Xing Lv, Xiong Zou, Yi-Jun Hua, Rui You, Qi Yang, Le Xia, Shao-Yan Guo, Wen Hu, Meng-Xia Zhang, Si-Yuan Chen, Mei Lin, Yu-Long Xie, Li-Zhi Liu, Rui Sun, Pei-Yu Huang, Wei Fan, Xiang Guo, Ming-Huang Hong & Ming-Yuan Chen. Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma. Cancer Commun (Lond). 2019, 39:75. doi:10.1186/s40880-019-0415-3


Export citations

EndNote

CJC Wechat 微信公众号


 

Editorial Manager


CC adopts ScholarOne Manuscripts to manage its submissions from Nov.1, 2019

 Submission Guidelines  

 

Reference style for  

 EndNote,
 Reference Manager



Editorial Manager


 

Year:

 

Month:

Advanced search

Subscription


CC is now published by Wiley

© Cancer Communications

651 Dongfeng Road East, Guangzhou 510060, P. R. China