Cancer Communications
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Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
Jing-Bo Wang, Xue Huang and Fu-Rong Li
Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College, Shenzhen People??s Hospital, Jinan University, 1017 Dongmen Road North, Shenzhen, 518020, Guangdong, P. R. China Shenzhen Cell Therapy Public Service Platform, Shenzhen, 218020, Guangdong, P. R. China
[Abstract] Lung cancer is the leading cause of cancer mortality worldwide. Dendritic cells (DCs) are the key factors providing protective immunity against lung tumors and clinical trials have proven that DC function is reduced in lung cancer patients. It is evident that the immunoregulatory network may play a key role in the failure of the immune response to terminate tumors. Lung tumors likely employ numerous strategies to suppress DC-based anti-tumor immunity. Here, we summarize the recent advances in our understanding on lung tumor-induced immunosuppression in DCs, which affects the initiation and development of T-cell responses. We also describe which existing measures to restore DC function may be useful for clinical treatment of lung tumors. Furthering our knowledge of how lung cancer cells alter DC function to generate a tumor-supportive environment will be essential in order to guide the design of new immunotherapy strategies for clinical use.
Cancer Communications   Epub date: 7/15/2019   doi:10.1186/s40880-019-0387-3
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Jing-Bo Wang, Xue Huang and Fu-Rong Li. Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives. Cancer Commun (Lond). 2019, 39:43. doi:10.1186/s40880-019-0387-3


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