Cancer Communications
indexed by SCI
BMC

Review
Parkinson’s disease-associated protein Parkin: an unusual player in cancer
Juan Liu, Cen Zhang, Wenwei Hu and Zhaohui Feng
Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, USA
[Abstract] The mutation of the Parkin gene is a cause of familial Parkinson’s disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role and mechanism of Parkin in cancer.
Cancer Communications   Epub date: 2018-6-26   doi:10.1186/s40880-018-0314-z   [ PDF Full-text ]   


 

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